Our Solution and Device Design Concept

Our device will noninvasively obtain measurements for each component of the Bramwell-Hill equation. The following figure summarizes the components of the device:

Our device will use waveforms from two locations to compute PWV, a highly reproducible metric. The final two parameters, blood density and ATVT, are determined from existing patient data. Most ICU patients undergo blood tests, so their individual blood densities will be available. If this information is not available, a constant average blood density value of 1.03 g/mL can be used, as changes in blood density due to temperature and pressure fluctuations are typically negligible. ATVT can be estimated robustly using cardiology tables based on a patient’s weight and height measurements. Machine learning will be applied here to more accurately predict individual ATVT using training data from the cardiology tables based on patient height and weight. Overall, the aforementioned measurements will be combined with a pressure waveform-derived HR in a central processing unit to indirectly measure CO using the Bramwell-Hill equation.

Our device has noted benefited over the current clinical standard, the pulmonary artery catheter (PAC), as shown in the following figure:

Supporting literature:

I. Wilkinson, S. Fuchs, I. Jansen, J. Spratt, G. Murray, J. Cockcroft and D. Webb, 'Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis', Journal of Hypertension, vol. 16, no., pp. 2079-2084, 1998.

J. Tu, K. Inthavong and K. Wong, ‘Fluid Properties of Blood’, Computational hemodynamics, pp 68. 2012.